Eventually, the Man is sent into future, where he is given a power source that renders him of no further use in the eyes of his captors, who plan to execute him. He is rescued by the future dwellers, who offer to bring him to their time; however, he instead chooses to be sent back to the moment of his childhood memory to meet with the woman once more. As he approaches her, he is surprised by one of his jailers who says he is unable to escape fate before gunning him down, revealing he had witnessed his own death as a child.

Cole and Railly finally learn that the Twelve Monkeys' plan was merely to release zoo animals in protest, and the true party responsible for the outbreak is Dr. Peters, an assistant of their leader's father and a radical apocalyptist. Cole tries to stop him at the airport but is gunned down by security, which is witnessed by his child self and revealed as the source of his memory. Peters briefly meets one of the scientists from the future on his plane.

Abe sees the slaves as the life blood of the Vampires and becomes an Abolitionist in order to stop the flow of slave blood.

Abe wants to end slavery because of his black friend from childhood, Johnson. He is warned by Sturgess to stick to the hunting plan.

In the book, Sir Thomas Langley turns out to have been carrying a letter from Edward II which explains that he (Edward III) survived the assassination, thanks to Thomas. Thomas hides the letter as insurance, but Merthin knows where it is and digs it up after Thomas's death from old age.

In the miniseries, Sir Thomas Langley *IS* King Edward II, who survived the assassination attempt by his wife. What he buries for insurance is his royal seal.

Doc brings Coy to Hope's house.

He is at the airport and receives a call from Hope about Coy arriving.

Bella screams and stops Edward from stepping into the sunlight in Italy.

She doesn't scream and Edward is exposed in the sunlight for a moment before being pushed back into the shadows.

Dracula is not shown to particularly love Mina or any other woman from his past.

Dracula falls in love with Mina because he believes she is a reincarnation of his dead sweetheart, Elisabeta.

Melony was an orphan that was in love with Homer and spends her life searching for him. When she finds him she realizes she isn't.

She doesn't exist.

In the book, Templeton says, “The old sheep was right. This fair is a rat’s paradise” when he recalls what the old sheep had told him about food being spilled at a fair.

In the movie, Templeton says, “The goose was right. This fair is a rat’s paradise” when he sees all the food spilled at the fair.

Donna was having an affair with Steve Kemp, but breaks up with him. They do not have sex during the story.

Donna is seen having sex with Steve prior to breaking up with him.

Ryan undergoes firearms training and Cathy periodically changes her daily routine to hinder terrorist reprisals.

Neither change their daily activities in response to the threats on their lives.